TEX261 is a 196 amino acid multi-pass membrane protein that belongs to the SVP26 family. The gene that encodes TEX261 consists of approximately 47,406 bases and maps to human chromosome 2p13.3. Consisting of 237 million bases, Chromosome 2 encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr syndrome, is due to mutations in the ALMS1 gene.