ABCC2 (Human) Recombinant Protein (Q01)
产品名称: ABCC2 (Human) Recombinant Protein (Q01)
英文名称: ABCC2 (Human) Recombinant Protein (Q01)
产品编号: H00001244-Q01
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human ABCC2 partial ORF ( NP_000383, 214 a.a. - 313 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- LKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKA
- Theoretical MW (kDa):
- 36.74
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
- Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 1244
- GeneBank Accession#:
- NM_000392
- Protein Accession#:
- NP_000383
- Gene Name:
- ABCC2
- Gene Alias:
- ABC30,CMOAT,DJS,KIAA1010,MRP2,cMRP
- Gene Description:
- ATP-binding cassette, sub-family C (CFTR/MRP), member 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq
- Other Designations:
- OTTHUMP00000020267,canalicular multispecific organic anion transporter
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Alzheimer Disease
- Arthritis, Rheumatoid
- Bile Duct Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Ductal, Breast
- Carcinoma, Endometrioid
- Carcinoma, Non-Small-Cell Lung
- Cholangiocarcinoma
- Cholestasis, Intrahepatic
- Colon cancer
- Colonic Neoplasms
- Colorectal Neoplasms
- Cystadenocarcinoma, Serous
- Diarrhea
- Disease Progression
- Drug Toxicity